Pathophysiology of Alzheimer’s disease

Pathophysiology of Alzheimer’s disease

Pathophysiology of Alzheimer’s disease — It is the most common form of dementia a neurological disease characterized by loss of mental ability, where is severe enough to interfere with normal activities of day to day life introduction a person with Alzheimer’s disease has gradual decline in mental functioning, begins with Flight memory loss followed by loss in the abilities to maintain employment to plan and execute familiar task and two reason and exercise judgement communication abilities, mood and personality and also affected Alzheimer’s disease is 4th leading cause of death in adult after heart diseases cancer and stroke.

Etiology

The case has genetical links disease destroyed neurones Nerve cells of the brain that controls memory including the hippocampus which control short term memory leading to short term memory failure and there is decrease inability to perform familiar tasks letter on, it affect the cerebral cortex responsibility responsible for the language and reasoning with the loss in in ability to make judgement personality changes occur which include emotional outburst when trying and agitation the stability of these changes increase with disease progression slowly many other areas of the brain get involved the brain drinks and loss functions does person become bed ridden incontinent helpless and non-responsive.

Pathophysiology of Alzheimer’s disease

The autopsy shows the brain once affected Court related with abnormal structures called neurofibril tangles and amyloid plaques neurofibrillary tangles are twisted mass of protein fibres inside Nerve cells in LG mass disease top protein which binds and stabilizer parts of neurones are chemically changed, become twisted and Tangled and no longer can stabilize the neurones amyloid plexus contains of insoluble deposits of Beta amyloid protein fragment from large protein called amyloid precursor protein, mix with parts of neurones and non Nerve cells flakes are found in the spaces between Nerve cells and a plane does mental changes of allergy disease is by interfering with the normal communication between neurones in the brain and later on leading to death of neurone two types of allergy exist familiar Alzheimer’s disease which is rare autosomal dominant inherited disease and sporadic Alzheimer’s disease with no obvious inheritance pattern.

Symptoms

The symptoms of Alzheimer’s disease begins with memory lapse like forgetting where the car keys are and it progress to more disturbing losses such as forgetting he or she can even drive the car he may forget that name of the family members forget what was said at the beginning of the sentence by the time he he he hears the and with the progression of Alzheimer’s disease other symptoms that include inability to perform routine task of judgement and personality behaviour changes can be seen some adverse things some Alchemist disease have trouble sleep and may suffer with confusion are agitation in the evenings in some cases person with Alzheimer’s disease repeat Same Idea movement words thoughts in the final stages people may have severe problem with eating communication and controlling their bladder and bubble functions bubble functions.

Diagnosis in Pathophysiology of Alzheimer’s disease

There are several types of oral and written test are used to help in diagnosis of Alzheimer’s disease which includes test of mental status, functional abilities, memory and concentration the diagnosis process is to evaluate the patient for depression and delirium sins of these can be present with army be mistaken for it delirium involves a decrease in consciousness or Awareness of one’s environment where the depression and memory loss both are common in the elderly people and combination of both can make wrong decision mistaken for Alzheimer’s disease on the other hand depression can be risk factors for Alzheimer’s disease.

Treatment¬† in Pathophysiology of Alzheimer’s disease

The people with Alzheimer’s disease are depressed are anxious and suffering from sleeplessness poor nutrition and Poor health each of these condition is treatable to some degree other psychiatric symptoms such as depression and anxiety hallucination and delusion may be treated with drugs if necessary that drug for treatment of Alzheimer’s disease act by increasing the levels of chemical neurotransmitters in the brain to make up for the decreased in decreased communication abilities all act by inhibiting the activity of textile cholinesterase which is enzyme that is broken down hairstyle clean and important neurotransmitter released by the neurone that is necessary for cognitive functions this drug increase the cognition and improve 172 perform normal activities of daily living.

Prevention

The treatment discussed above reduce the risk of developing the disease the prevention of Alzheimer’s disease is focused on blocking the production of amyloid in the brain as the last breaking down beta-amyloid once it is released from the cell but before it aggregates into insoluble plake the studies are conducted to develop and Alzheimer’s disease vaccine where immune response may result in the elimination of the formation of amyloid plexus..

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